Topical Application of Fumaric Acid Derivatives

Use of fumaric acid esters in psoriasis.

Fumaric acid esters (FAE) are chemical compounds derived from the unsaturated dicarbonic acid fumaric acid. The usage of FAEs in treatment of psoriasis was introduced in the late 1950's. In the 1980s more standardized oral preparations of FAEs were developed containing dimethylfumarate (DMF) and salts of monoethylfumarate (MEF) as main compounds. In 1994, Fumaderm an enteric-coated tablet conta...

Fumaric Acid Derivatives in Rodent Cells and Induction of Glutathione Transferases and NAD(P)H:Quinone

Dimethyl fumarate and dimethyl maléate are potent inducers of cytosolic NAD(P)H:(quinone acceptor) oxidoreductase (here designated uninone reducÃ-ase)activity in Hepa Iclc? murine hepatoma cells in culture, whereas fumarie and maleic acids are much less potent, in agreement with the much greater reactivity of the esters as Michael reaction acceptors (P. Talalay, M. J. De Long, and H. J. Procha...

a green synthesis of tetrahydrobenzo[b]pyran derivatives throughthree-component condensation using fumaric acid

Microsoft Word - DRM253BF

Dr. Ulrich Schmid, 17, rue de l’Hôtel de Ville, CH-1800 Vevey (Suisse) We read with great interest the paper on the risk of sensitization upon topical application of fumaric acid derivatives by de Haan et al. [1]. Although in our wide personal experience oral dimefhylfumarates have proven effective in psoriasis in 70% of the cases, it cannot be emphasized enough that topical application should ...

Microsoft Word - DRM253BF

Dr. Ulrich Schmid, 17, rue de l’Hôtel de Ville, CH-1800 Vevey (Suisse) We read with great interest the paper on the risk of sensitization upon topical application of fumaric acid derivatives by de Haan et al. [1]. Although in our wide personal experience oral dimefhylfumarates have proven effective in psoriasis in 70% of the cases, it cannot be emphasized enough that topical application should ...